Vilitra (vardenafil) can be taken safely with some medicines, but it has several important interactions. It should not be assumed safe with every medication. Medicines that are especially important Nitrates: Do not take Vilitra with nitroglycerin/GTN, isosorbide mononitrate, or isosorbide dinitrate. The combination can cause a dangerous drop in blood pressure. M Medicines.org.uk +1 Riociguat: This should not be combined with vardenafil because of the risk of severe low blood pressure. M Medicines.org.uk Alpha-blockers such as tamsulosin, alfuzosin, or terazosin: they can further lower blood pressure, so vardenafil may need a lower dose and careful timing. M Medicines.org.uk Certain antibiotics/antifungals, including clarithromycin, erythromycin, ketoconazole, and itraconazole, can increase vardenafil levels and may require dose adjustment or avoidance. M Medicines.org.uk Other ED medicines such as sildenafil (Cenforce/Fildena) or tadalafil (Vidalista): don't combine them with Vilitra. M Medicines.org.uk Some heart-rhythm medicines (for example amiodarone or sotalol) require particular caution because vardenafil can affect the QT interval. M Medicines.org.uk If you give me the names and doses of all the medicines/supplements you're currently taking, I can check them specifically against Vilitra and tell you which combinations are safe, which need caution, and which should be avoided.