Tadarise 60 mg contains tadalafil, a medicine used to treat erectile dysfunction. Combining tadalafil with nitrates can cause a sudden, potentially life-threatening drop in blood pressure. Nitrates include: Nitroglycerin (GTN), including tablets, sprays and patches used for angina. Isosorbide mononitrate and isosorbide dinitrate. Recreational nitrites, sometimes called “poppers.” If you have already taken Tadarise 60 mg: Do not use nitrate medication yourself for at least 48 hours after tadalafil; even after 48 hours, nitrates should only be considered by medical professionals under close monitoring. DailyMed +1 If you develop chest pain, call emergency services immediately and tell them when you took tadalafil. Do not take your own nitroglycerin. Have you already taken Tadarise 60 mg, and do you take a nitrate such as nitroglycerin or isosorbide for a heart condition? I can help you understand the safest next step.