Malegra DXT Plus is taken orally, and both of its active ingredients are absorbed through the gastrointestinal (GI) tract. After swallowing the tablet, it first dissolves in the stomach, but the main site of absorption is the small intestine (especially the jejunum). This is where most drug absorption into the bloodstream happens because of the large surface area and rich blood supply. Sildenafil (for erection support) is absorbed fairly quickly in the small intestine and typically reaches peak blood levels within about 30–120 minutes. Duloxetine (for ***** control and anxiety-related effects) is also absorbed in the small intestine and then processed in the liver before entering systemic circulation. Food, especially high-fat meals, can slow down the absorption of sildenafil and delay its onset of action. So, in simple terms: Malegra DXT Plus is mainly absorbed in the small intestine after oral intake.