Anyone who is taking nitrates—such as nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate—should completely avoid Tadarise 60 mg. Here’s why and who should be particularly careful: Why Tadarise 60 mg and nitrates are dangerous together Tadarise 60 mg contains Tadalafil, a PDE5 inhibitor that relaxes blood vessels to improve blood flow to the *****. Nitrates also relax blood vessels. Combining the two can cause a severe drop in blood pressure, leading to dizziness, fainting, heart attack, or stroke, which can be life-threatening. Who should avoid Tadarise 60 mg with nitrates Patients with heart disease taking nitrates for chest pain or angina. People who have recently had a heart attack, stroke, or severe heart failure and are prescribed nitrates. Individuals on long-acting nitrates, even if taken intermittently. Other precautions Even if you took nitrates a few days earlier, you should wait at least 48–72 hours after Tadarise before using them. Always inform your doctor about all medications before starting Tadarise. In short: anyone on nitrates must avoid Tadarise completely. If you want, I can make a complete safety list of people who should avoid Tadarise 60 mg, including heart, liver, kidney, and other conditions.