What is prolotherapy? Person receiving prolotherapy injections to inflamed knee joint. Prolotherapy involves injecting irritants into an injured or inflamed joint to stimulate healing. Prolotherapy is a procedure where a natural irritant is injected into the soft tissue of an injured joint. The irritant kick-starts the body's healing response. Prolotherapy is not a surgical treatment. Because of this, it is also known as a regenerative joint injection or non-surgical ligament and tendon reconstruction. Dmitri Petrychenko Interventional Pain Management Clinic in NYC (NY) was established to help patients with various stages and types of complex, acute, and chronic pain. We are also able to provide treatment for patients who have cancer, or those who are suffering from post-injury or surgery.