Malegra 120 contains sildenafil citrate, a PDE5 (phosphodiesterase type 5) inhibitor. Here's how it improves blood flow during ***** activity: Works to Improve Blood Flow ***** Arousal Triggers Nitric Oxide (NO) Release During ***** stimulation, nerves in the ***** release nitric oxide. Nitric Oxide Activates cGMP Nitric oxide increases levels of cyclic guanosine monophosphate (cGMP) — a chemical that relaxes the smooth muscle cells in the walls of blood vessels. Smooth Muscle Relaxation This relaxation causes the arteries in the ***** to widen (vasodilation), allowing more blood to flow into the erectile tissue (corpora cavernosa). PDE5 Normally Breaks Down cGMP The enzyme PDE5 degrades cGMP, reducing blood flow and ending the erection. Sildenafil (in Malegra 120) Blocks PDE5 Malegra 120 inhibits PDE5, allowing cGMP to remain active longer. This prolongs smooth muscle relaxation and enhances blood flow, making it easier to get and maintain an erection during ***** activity. Onset and Duration Takes effect: Usually within 30 to 60 minutes of taking it. Duration: Effects can last up to 4–6 hours, depending on the individual. Important Notes It does not cause an erection without ***** stimulation. Should not be taken with nitrates or alpha-blockers. Consult your doctor before using it, especially if you have cardiovascular conditions.