Tadalista 10 mg contains tadalafil at a lower dose, but even at 10 mg, it is not recommended in certain situations due to the risk of serious side effects. Situations when Tadalista 10 mg is not recommended: Heart problems: Recent heart attack or stroke (within the last 6 months) Severe heart failure or unstable angina Low blood pressure or uncontrolled high blood pressure Risk of dizziness, fainting, or heart complications Use of nitrates or nitric oxide donors e.g., nitroglycerin, isosorbide mononitrate Can cause dangerous drop in blood pressure Severe liver or kidney impairment May need dose adjustment or avoidance Allergy to tadalafil or other PDE5 inhibitors Rash, swelling, or difficulty breathing after use History of certain eye conditions Non-arteritic anterior ischemic optic neuropathy (NAION) Severe vision problems Structural heart problems Hypertrophic obstructive cardiomyopathy, severe aortic stenosis Blood disorders Sickle cell anemia, leukemia, or multiple myeloma (risk of prolonged erections) Use of other ED medications or certain drugs that interact with tadalafil Certain antifungals, antibiotics, or HIV medications