Vidalista 60 contains tadalafil 60 mg, which is a high-dose PDE5 inhibitor. Indigestion (dyspepsia) is a known side effect of tadalafil, and higher doses like 60 mg increase the likelihood. Here’s why: Why Indigestion Happens Relaxation of Smooth Muscles Tadalafil not only relaxes the blood vessels in the ***** but can also relax smooth muscles in the stomach and esophagus, slowing digestion and causing bloating or heartburn. Increased Blood Flow to Organs PDE5 inhibitors can slightly alter blood flow to the gastrointestinal tract, leading to mild upset stomach or acid reflux. Dose-Dependent Effect Higher doses (like 60 mg) increase the concentration of tadalafil in the body, which makes side effects like nausea, indigestion, and back pain more common compared to standard 20 mg or 10 mg doses. Interaction with Meals Taking Vidalista 60 with heavy or fatty meals can worsen indigestion because high-fat foods slow gastric emptying.