Zenegra 100 mg contains Sildenafil Citrate, a PDE5 inhibitor used for erectile dysfunction (ED). Taking it on an empty stomach is often recommended because food, especially heavy or fatty meals, can delay its absorption and reduce effectiveness. Here’s why: How Food Affects Zenegra Slower absorption: Sildenafil is absorbed in the small intestine. Fatty or heavy meals slow stomach emptying, which delays the time it takes for the drug to reach the bloodstream. Reduced peak concentration: When taken with a large meal, the maximum level of the drug in your blood is lower. This can make it less effective or take longer to work. Timing matters: On an empty stomach, Zenegra 100 mg usually works in 30–60 minutes. After a heavy meal, it might take up to 2 hours to work. Practical Advice Take Zenegra 1 hour before ***** activity for best effect. If you eat, stick to light meals like fruits, toast, or yogurt rather than fatty or fried foods. Avoid alcohol with a heavy meal, as it can also reduce effectiveness and increase side effects like dizziness.